Multi-criteria optimization of batch composition for the hydrometallurgical for the hydrometallurgical process of zinc production

Ova doktorska disertacija ima za cilj definisanje originalnog algoritma za formiranje optimalne mešavine od raspoloživih koncentrata cinka, kroz sedam koraka, postupnim uvoĎenjem pojedinih metoda višekriterijumskog pristupa odlučivanju, u cilju definisanja integralnog modela za rangiranje pojedinih komponenti u mešavini i višekriterijumske optimizacije sastava šarže, kao inputa u tehnološki proces. Definisan je originalni AHP – OEW – PROMETHEE (GAIA) – TOPSIS model u fazi okruženju. Ovaj model zasnovan je na poreĎenju različitih koncentrata cinka prema kriterijumima koji su definisani u modelu (korisne komponente, štetne komponente, kao i nabavna cena koncentrata). Za rangiranje pojedinih vrsta koncentrata u sastavu šarže, korišćena je PROMETHEE (GAIA) metodologija, uz primenu AHP (Analytical Hierarchy Process) i OEW (Objective Entropy Weight) pristupa u dodeljivanju težinskih parametara kriterijumima. UvoĎenjem hibridnog modela F-PROMETHEE (Fazi PROMETHEE), vrednosti svake alternative u odnosu na kriterijume, predstavljene su kao fazi brojevi. U postupku definisanja Fazi TOPSIS metodologije, odreĎena su fazi pozitivna i fazi negativna idealna rešenja. Zatim, odreĎene su distance svih alternativa od idealno pozitivnog i idealno negativnog rešenja, što je omogućilo da se odrede relativne blizine idealnom rešenju za svaki od definisanih scenarija. Definisani hibridni model na primeru optimizacije sastava šarže za hidrometalurški postupak dobijanja cinka, predstavlja poboljšanje pristupa u rešavanju problema mešavine i kao takav može biti primenjen i na druge sisteme, s obzirom da u sebi sadrži elemente koji se mogu primeniti na bilo koji drugi sistem.This doctoral dissertation is dealing with the development of original algorithm for optimal mixture formation from available zinc concentrates, through seven steps, by introduction of certain methods of multi-criteria decision making approach, in order to define an integrated model for ranking the individual components in the mixture and multi-criteria optimization of the batch composition, as input in the technological process. The original AHP – OEW – PROMETHEE (GAIA) – TOPSIS model in the fuzzy environment is defined. This model is based on a comparison of different zinc concentrates according to the criteria defined in the model (useful components, harmful components, as well as the purchase price of concentrate). PROMETHEE (GAIA) methodology was used for the ranking of certain types of concentrates in the batch composition, by application of the AHP (Analytical Hierarchy Process) and the OEW (Objective Entropy Weight) approach in the allocation of the weight parameters for the optimization criteria. With the introduction of the hybrid Fuzzy PROMETHEE model, the value of each alternative in relation to the criteria, are presented as fuzzy numbers. In the process of defining the Fuzzy TOPSIS methodology, fuzzy positive and fuzzy negative ideal solution were determined. Then, the distances of all the alternatives from ideal positive and ideal negative solutions were determined, which enabled us to determine the relative closeness to the ideal solution for each of the defined scenarios. Defined hybrid model in the case of the batch composition optimization for the hydrometallurgical process of zinc production, represents an improvement of the approach for blending problem solving and as such can be applied to other systems, since it contains elements that can be applied to any other system

AN ANFIS – BASED AIR QUALITY MODEL FOR PREDICTION OF SO2 CONCENTRATION IN URBAN AREA

This paper presents the results of attempt to perform modeling of SO2concentration in urban area in vicinity of copper smelter in Bor (Serbia), using ANFIS methodological approach. The aim of obtained model was to develop a prediction tool that will be used to calculate potential SO2 concentration, above prescribed limitation, based on input parameters. As predictors, both technogenic and meteorological input parameters were considered. Accordingly, the dependence of SO2concentration was modeled as the function of wind speed, wind direction, air temperature, humidity and amount sulfur emitted from the pyrometallurgical process of sulfidic copper concentration treatment

International trade investment agreements as an indicator of postdemocary

Zadnja je dva desetljeća sociološku i politološku raspravu obilježila ideja da se nalazimo u postdemokratskom dobu, u kojem su formalne institucije liberalne demokracije i dalje na snazi, dok istovremeno financijske elite dominiraju svim sferama demokracije te bez etičkih kočnica, a s izrazitom moći utječu na ljudska, radnička i ekološka prava. Slikovit prikaz razvoja prema postdemokraciji jest sustav međunarodnih trgovinskih sporazuma te različiti mehanizmi u njega implementirani, poput sustava rješavanja sporova između investitora i država, koji daju toliku moć financijskim elitama da su one u mogućnosti direktno utjecati na sposobnost država da samostalno donose određene regulative

International trade investment agreements as an indicator of postdemocary

Zadnja je dva desetljeća sociološku i politološku raspravu obilježila ideja da se nalazimo u postdemokratskom dobu, u kojem su formalne institucije liberalne demokracije i dalje na snazi, dok istovremeno financijske elite dominiraju svim sferama demokracije te bez etičkih kočnica, a s izrazitom moći utječu na ljudska, radnička i ekološka prava. Slikovit prikaz razvoja prema postdemokraciji jest sustav međunarodnih trgovinskih sporazuma te različiti mehanizmi u njega implementirani, poput sustava rješavanja sporova između investitora i država, koji daju toliku moć financijskim elitama da su one u mogućnosti direktno utjecati na sposobnost država da samostalno donose određene regulative

Solving the Task Assignment Problem with a Variable Neighborhood Search

In this paper a variable neighborhood search (VNS) approach for the task assignment problem (TAP) is considered. An appropriate neighborhood scheme along with a shaking operator and local search procedure are constructed specifically for this problem. The computational results are presented for the instances from the literature, and compared to optimal solutions obtained by the CPLEX solver and heuristic solutions generated by the genetic algorithm. It can be seen that the proposed VNS approach reaches all optimal solutions in a quite short amount of computational time.* This research was partially supported by the Serbian Ministry of Science and Ecology under project 144007

Doking studije nekih jedinjenja sa pirazolom u aktivnom mestu ciklooksigenaze-2

Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but also in cancer, atherosclerosis, Alzheimer's disease, and Parkinson`s disease. Potential cardiovascular and hepatic side effects of cyclooxygenase-2 inhibitors have limited their use. The development of selective and safe cyclooxygenase-2 inhibitors remains a high priority in drug discovery. Based on the structure of previously investigated newly synthesized β-hydroxy-β-arylpropanoic acids, two groups of compounds were designed: analogs in which one of the benzene rings was replaced by a pyrazole, while the carboxyl group was retained, and amides of β-hydroxy-β-arylpropanoic acids with pyrazole. The compounds were docked into the 3D structure of the catalytic site of the enzyme cyclooxygenase-2 using AutoDock Vina 1.2.0. and the obtained interactions were compared with the interactions of celecoxib, a selective inhibitor. The amides had lower binding energies than the designed acids, which makes them attractive target compounds for synthesis and further examination.Neselektivni nesteroidni antiinflamatorni lekovi poput aspirina, ibuprofena i diklofenaka inhibiraju enzime ciklooksigenazu-1 i ciklooksigenazu-2, a selektivni inhibitori ciljaju ciklooksigenazu-2 koja je prekomerno izražena u inflamaciji, ali takođe i kod kancera, ateroskleroze, Parkinsonove i Alchajmerove bolesti. Potencijalni kardiovaskularni i hepatički neželjeni efekti selektivnih inhibitora ciklooksigenaze-2 su ograničili njihovu primenu. Razvoj selektivnih i bezbednih inhibitora ciklooksigenaze-2 ostaje veoma prioritetna oblast u otkrivanju lekova. Na osnovu strukture prethodno istraživanih novosintetisanih β-hidroksi-β-arilpropanskih kiselina dizajnirane su dve grupe jedinjenja: analozi u kojima je jedan od benzenovih prstenova zamenjen pirazolom, uz zadržavanje karboksilne grupe, i amidi β-hidroksi-β-arilpropanskih kiselina sa pirazolom. Program AutoDock Vina 1.2.0 je korišćen za dokovanje dizajniranih jedinjenja u 3D strukturu katalitičkog mesta enzima ciklooksigenaze-2, a ostvarene interakcije su upoređene sa interakcijama koje ostvaruje selektivni inhibitor celekoksib. Amidi su imali nižu energiju vezivanja od kiselina, što ih čini dobrim kandidatima za sintezu

The influence of induced mutagenesis on reproductive behavior of Drosophila subobscura and the role of sexual selection in relationto the level of mutational load

Prema teorijskim očekivanjima seksualna selekcija može smanjivati mutaciona opterećenja u populacijama. Mužjaci koji su boljeg genetičkog kvaliteta bi trebalo da budu uspešniji u parenju u poređenju sa mužjacima lošijeg genetičkog kvaliteta. Na taj način ženke, prilikom izbora partnera za parenje, mogu da eliminišu one mužjake koji nose štetne alele, i da smanje mogućnost prenošenja štetnih alela u sledeću generaciju. Seksualna selekcija će redukovati mutaciona opterećenja i povećavati adaptivnu vrednost populacije, ako je većina mutacija štetna i za adaptivnu vrednost i za osobine koje utiču na uspešnost mužjaka u parenju. Istraživanja poslednjih godina su dala rezultate koji idu u prilog ovoj teoriji, ali i oprečne rezultate. Ovakva kontradiktornost proizilazi iz kompleksnosti problematike usled različitih reproduktivnih strategija vrsta, kao i različitih reproduktivnih strategija mužjaka i ženki. Takođe, osobine koje utiču na komponente adaptivne vrednosti, kao i na uspešnost u parenju, su veoma složene, pod determinacijom velikog broja gena, i u čijoj osnovi leže kompleksne genske interakcije. Iako se kao osobine koje su cilj seksualne selekcije najčešće analiziraju sekundarne polne karakteristike, i mnoge druge osobine određuju atraktivnost mužjaka. To su i morfološke, fiziološke, ponašajne i druge osobine koje utiču na uspešnost u parenju, a mogu se nazvati osobinama koje su zavisne od opšteg stanja mužjaka (eng. condition-dependent traits)...According to theoretical predictions sexual selection can reduce mutational load in populations. Males of good genetic quality should be more successful in matings, compared to the males of low genetic quality. In this way females, through the choice of mating partners, can eliminate males carriers of deleterious alleles, and reduce transmission of deleterious alleles to the next generation. Sexual selection will purge mutational load and increase fitness if most mutations were deleterious to both nonsexual fitness and condition-dependent traits affecting mating success. Studies in recent years have yielded results that support this theory, but opposite results are obtained, as well. This contradiction arises from different reproductive strategies of species, and different reproductive strategies of males and females. Traits that affect fitness components, as well as mating success, are under polygenic determination, with very complex gene interactions. Although secondary sexual traits were usually analyzed as target of sexual selection, many other traits can determine male attractiveness. Traits such as morphological, physiological, behavior and other, affecting mating success, can be termed as condition-dependent traits. In order to test this hypothesis, that sexual selection can reduce mutational load, two experimental groups were formed from the same population genetic pool of Drosophila subobscura, which differed in the level of mutational load. Mutations were induced in one group, using 30Gy ionizing radiation. The effect of sexual selection in reduction of mutational load was measured through different components of male mating behavior (courtship occurrence, courtship latency, courtship intensity, mating occurrence,latency to mating and duration of mating)...

The influence of induced mutagenesis on reproductive behavior of Drosophila subobscura and the role of sexual selection in relationto the level of mutational load

Prema teorijskim očekivanjima seksualna selekcija može smanjivati mutaciona opterećenja u populacijama. Mužjaci koji su boljeg genetičkog kvaliteta bi trebalo da budu uspešniji u parenju u poređenju sa mužjacima lošijeg genetičkog kvaliteta. Na taj način ženke, prilikom izbora partnera za parenje, mogu da eliminišu one mužjake koji nose štetne alele, i da smanje mogućnost prenošenja štetnih alela u sledeću generaciju. Seksualna selekcija će redukovati mutaciona opterećenja i povećavati adaptivnu vrednost populacije, ako je većina mutacija štetna i za adaptivnu vrednost i za osobine koje utiču na uspešnost mužjaka u parenju. Istraživanja poslednjih godina su dala rezultate koji idu u prilog ovoj teoriji, ali i oprečne rezultate. Ovakva kontradiktornost proizilazi iz kompleksnosti problematike usled različitih reproduktivnih strategija vrsta, kao i različitih reproduktivnih strategija mužjaka i ženki. Takođe, osobine koje utiču na komponente adaptivne vrednosti, kao i na uspešnost u parenju, su veoma složene, pod determinacijom velikog broja gena, i u čijoj osnovi leže kompleksne genske interakcije. Iako se kao osobine koje su cilj seksualne selekcije najčešće analiziraju sekundarne polne karakteristike, i mnoge druge osobine određuju atraktivnost mužjaka. To su i morfološke, fiziološke, ponašajne i druge osobine koje utiču na uspešnost u parenju, a mogu se nazvati osobinama koje su zavisne od opšteg stanja mužjaka (eng. condition-dependent traits)...According to theoretical predictions sexual selection can reduce mutational load in populations. Males of good genetic quality should be more successful in matings, compared to the males of low genetic quality. In this way females, through the choice of mating partners, can eliminate males carriers of deleterious alleles, and reduce transmission of deleterious alleles to the next generation. Sexual selection will purge mutational load and increase fitness if most mutations were deleterious to both nonsexual fitness and condition-dependent traits affecting mating success. Studies in recent years have yielded results that support this theory, but opposite results are obtained, as well. This contradiction arises from different reproductive strategies of species, and different reproductive strategies of males and females. Traits that affect fitness components, as well as mating success, are under polygenic determination, with very complex gene interactions. Although secondary sexual traits were usually analyzed as target of sexual selection, many other traits can determine male attractiveness. Traits such as morphological, physiological, behavior and other, affecting mating success, can be termed as condition-dependent traits. In order to test this hypothesis, that sexual selection can reduce mutational load, two experimental groups were formed from the same population genetic pool of Drosophila subobscura, which differed in the level of mutational load. Mutations were induced in one group, using 30Gy ionizing radiation. The effect of sexual selection in reduction of mutational load was measured through different components of male mating behavior (courtship occurrence, courtship latency, courtship intensity, mating occurrence,latency to mating and duration of mating)...

Intelligent textiles and sports clothing

Special purpose fibers were found only in the middle of the last century and since then the possibility of their application has been studied. These fibers are used in the production of clothing that requires specific protective functions such as: protection against fi re and heat, ballistic protection, protection against various types of radiation, protection against nuclear, biological and chemical effects, sportswear etc...The new generation of textiles, intelligent textiles, no longer serves only as protection, but it can receive and recognize stimuli from the environment and respond to them

Are we going the same way? American and European perspectives in fighting corruption

U ovom radu autori ispituju različite načine sprječavanja i borbe protiv korupcije u nekoliko pravnih sustava. Također daju informacije o međunarodnim instrumentima s kojima su usklađene unutarnje politike i zakonodavstva država. Razmatrajući dva velika pravna sustava Europsku uniju i SAD, autori daju uvid u dva načina borbe protiv korupcije. Premda ne postoji određena razlika u zakonodavnom pristupu Europske unije s jedne strane i SAD-a i Kanade s druge strane, postoje razlike u praksi. Razlike su na operativnom i institucionalnom nivou, ali ne i u javnim politikama. Posebna je pozornost u ovome članku poklonjena pravnim osobama kao nositeljima kaznene odgovornosti što je posljedica različitih teoretskih pristupa prihvaćenih u određenim sustavima pod kojima se pravna osoba smatra kazneno odgovornom. Dok je u SAD-u vrlo lako proglasiti pravnu osobu kazneno odgovornom, u Velikoj Britaniji, Kanadi i nekim drugim zemljama Europske unije to je povezano s određivanjem odgovorne osobe na višim razinama u strukturi pravnih osoba